The Vitamin D, Ionised Calcium and Parathyroid Hormone Axis of Cerebral Capillary Function: Therapeutic Considerations for Vascular-Based Neurodegenerative Disorders

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The Vitamin D, Ionised Calcium and Parathyroid Hormone Axis of Cerebral Capillary Function: Therapeutic Considerations for Vascular-Based Neurodegenerative Disorders

Blood-brain barrier dysfunction characterised by brain parenchymal extravasation of plasma proteins may contribute to risk of neurodegenerative disorders, however the mechanisms for increased capillary permeability are not understood. Increasing evidence suggests vitamin D confers central nervous system benefits and there is increasing demand for vitamin D supplementation. Vitamin D may influen...

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Background and Objective: Tuberculosis (TB) remains an ongoing major public health problem in the world. In recent years, experimental evidenc suggests a link between TB and Vitamin (Vit) D. This study was conducted to determine serum Vit D, calcium (Ca), phosphorus (P), and parathormone (PTH) levels in untreated pulmonary TB (PTB) patients. Materials and Methods: In this case control study, 5...

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Interrelationships of Vitamin D and Parathyroid Hormone in Calcium Homeostasis.

IN man and most mammals the concentration of calcium in the blood and body fluids remains almost constant under normal conditions, with only slight fluctuations. For the various cellular functions which are dependent on calcium, for example neuromuscular transmission, it is the ionized fraction of calcium (approximately 50 per cent of the total serum calcium level) which is important, and it is...

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Parathyroid hormone and vitamin D.

Along with many others of my generation at the Yale School of Medicine and the New Haven Hospital, I owe a great debt to Grover Powers as an inspiring teacher, friend, and benefactor. The invitation to give the Grover Powers lecture at Yale had a special emotional significance, therefore, and it is with a sense of great privilege that I address you this afternoon. I do not consider the primary ...

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ژورنال

عنوان ژورنال: PLOS ONE

سال: 2015

ISSN: 1932-6203

DOI: 10.1371/journal.pone.0125504